In the childhood ALL cell lines CCRF-CEM (T cell acute lymphoblastic leukemia, T-ALL), NALM6 (B cell acute lymphoblastic leukemia, B-ALL) and REH (B-ALL), Leclerc et al. 91 demonstrated that AMPK activation induced growth inhibition and apoptosis via the downregulation of mTOR phosphorylation on serine 2448. This evidence concerns the gene MTOR and acute lymphoblastic leukemia.