However, another study showed that in high-grade squamous intraepithelial lesions (HSILs) and cervical cancer associated with HPV16 infection, the expression of the NK-activating receptors NKp30, NKp45 and NKG2D (only in cervical cancer) is considerably decreased, which affects the cytolytic functionality of cells and may contribute to tumor progression 32. The gene discussed is KLRK1; the disease is cervical carcinoma.