AFDN and acute myeloid leukemia: The adhesion molecule Afadin (AF‐6), encoded by theMLLT4 gene, is localised at cell‐cell adhesion sites in epithelial cells and fibroblasts to help the formation of adherens junctions (AJs) and maintain cell polarity.15, 16, 17 Originally identified as a fusion partner of the MLL gene in acute myeloid leukaemia with chromosome translocation,18 AF‐6 is also associated with initiation and progression of solid tumours.