TIMPs were increased in the plasma of untreated children with JIA, have been associated with levels of matrix metalloproteinase (MMP)-1, MMP-3, and TIMP1 in paired serum and synovial fluid also in those with JIA, and were found in AqH of patients with glaucoma [32, 33, 35]. The gene discussed is MMP3; the disease is juvenile idiopathic arthritis.