Up to 60–70% of the ARVC index cases carry a causal desmosomal [such as plakophilin-2 (PKP2) or desmoglein-2 (DSG2)] gene mutation, but various non-desmosomal genes may also be involved (35, 36), including SCN5A (37). The gene discussed is SCN5A; the disease is arrhythmogenic right ventricular cardiomyopathy.