Consistent with our findings in in silico analyses, we observed in both assays higher expression of Plexin C1 in PLC/PRF/5, HEP3B, HEPG2 and HUH7 HCC cells with epithelioid phenotype compared to its highly downregulated expressions in SNU387, SNU423, SNU398 and SK-HEP1 HCC cell lines with mesenchymal characteristics (Figure 3). This evidence concerns the gene PLXNC1 and hepatocellular carcinoma.