These findings are in keeping with a previously published paper showing that, in comparison to sucrose, a diet enriched in D-tagatose as a carbohydrate source did not promote obesity, hyperglycemia, or adipocyte hypertrophy and resulted in a lesser extent of hypercholesterolemia and atherosclerosis, when tested in low-density lipoprotein receptor-deficient (LDLr−/−) mice [23]. The gene discussed is VLDLR; the disease is obesity due to melanocortin 4 receptor deficiency.