NR3C2 and hydrops fetalis: Most importantly, the presence of this association has been confirmed in human settings since MR antagonist addiction contributes to a reduction in mortality and HF hospitalization (ESC HF guidelines 2016 https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Acute-and-Chronic-Heart-Failure): a direct correlation between Aldo and mortality in patients with severe HF was shown in the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS); the 6-month mortality rate was higher in HF patients with elevated Aldo levels [90, 92].