HSPG2 and systemic sclerosis: In order to explore the effect of TGF-β signaling blockade on HSPG2 in SSc patients, we used our previously generated microarray data from our clinical trial of a TGF-β blocking antibody, fresolimumab (for patient characteristics, study details, outcomes and microarray data, refer to (16), Clinicaltrials.gov NCT01284322, GEO database accession number GSE55036).