A number of proinflammatory mediators, such as interleukin (IL)-1, 6, 8, and tumor necrosis factor (TNF)-α, were shown to play a role in AP in experimental animals (Norman et al., 1997; Liu et al., 2003; Meng et al., 2005) and in human patients (de Beaux et al., 1996; McKay et al., 1996; Brivet et al., 1999; Mayer et al., 2000). This evidence concerns the gene TNF and alkaline phosphatase measurement.