GPC3 and neoplasm: As shown in the Figure 8, both wild-type GPC3-CAR T cells and those with deficient PD-1 significantly (P < 0.001) inhibited the expression of the three tumor-related genes in xenografts, and the PD-1 deficient GPC3-CAR T cells caused the inhibition at a significantly (P < 0.001) larger degree compared with wild-type GPC3-CAR T cells.