MAPT and Alzheimer disease: Alzheimer’s disease (AD) neuropathology is characterized by intraneuronal protein clusters of hyperphosphorylated Tau protein (neurofibrillary tangles) and extracellular amyloid beta (Aβ) protein aggregation that start decades before the occurrence of clinical symptoms (Bateman et al., 2012; Epelbaum et al., 2017).