More recent neuro-pathological studies show that SOM-interneurons, in the anterior olfactory nucleus, the piriform cortex (with co-localization of Aβ1–42; Saiz-Sanchez et al., 2015), the amygdala and entorhinal cortex are early involved in AD process (Saiz-Sanchez et al., 2016). The gene discussed is GRHL3; the disease is Alzheimer disease.