Alzheimer’s disease (AD) neuropathology is characterized by intraneuronal protein clusters of hyperphosphorylated Tau protein (neurofibrillary tangles) and extracellular amyloid beta (Aβ) protein aggregation that start decades before the occurrence of clinical symptoms (Bateman et al., 2012; Epelbaum et al., 2017). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.