Interestingly, genetic evidence suggests an association between altered NRG1/ErbB signaling and drug of abuse dependance (Han et al., 2012) as well as autism (Yoo et al., 2015), thus indicating that a dysfunction in ErbB-dependent regulation of mGluR1-activated LTD might be a contributing neurobiological mechanism underlying these diseases. This evidence concerns the gene EGFR and autism.