Notably, increasing evidence supports the contribution of mGluR1-dependent mechanisms in the pathogenesis of neurological and psychiatric disorders, such as schizophrenia, PD, addiction and autism (Ferraguti et al., 2008; Lesage and Steckler, 2010;Lüscher and Huber, 2010; Herman et al., 2012), which are characterized by alterations in midbrain DA transmission and also supposed to be linked to NRG1/ErbB dysfunctions (Han et al., 2012; Iwakura and Nawa, 2013; Mei and Nave, 2014; Ikawa et al., 2017). This evidence concerns the gene GRM1 and Parkinson disease.