EGFR and Parkinson disease: Thus, ErbB signaling activation fosters morphological/biochemical differentiation of immature DA cells (Casper et al., 1991; Ferrari et al., 1991;Casper and Blum, 1995;Farkas and Krieglstein, 2002; Zhang et al., 2004) and protects midbrain DA neurons from neurotoxin-induced degeneration either in neuronal cultures (Ostenfeld et al., 1999; Hanke et al., 2004; Zhang et al., 2004; Iwakura et al., 2005) or in mice models of Parkinson’s diseases (PD) (Carlsson et al., 2011; Depboylu et al., 2015).