In fact, these observations are natural because CRP is predominantly secreted by the liver in response to an elevated IL-6 level [37], which was already reported to be a major independent risk factor for fetal and neonatal disorders associated with neonatal hearing impairment, such as FIRS, funisitis, early onset neonatal sepsis, and WMI in preterm infants [9, 10, 21, 33, 38]. This evidence concerns the gene CRP and Neonatal sepsis.