Previous studies from our group suggested that serum paraoxonase-1 (PON1) and the chemokine (C-C) motif ligand 2 (CCL2) might be useful biomarkers of PAD [21, 22]: PON1 being a scavenger of excessive reactive oxygen species [23] and CCL2 an inducer of monocyte migration and differentiation into macrophages [24]. Here, PON1 is linked to peripheral arterial disease.