While these changes are important, it is now clear that the anti- or pro-tumourigenic nature of the lymphoid infiltrate is not only dependent on the specific type and ratio of various lymphocytes (CD4+ “helper” T cells, CD8+ cytotoxic T cells, cytotoxic NK cells, regulatory T cells), but also their location within the tumour, and the context of the surrounding cellular (e.g. myeloid cells, dendritic cells) and the cytokine milieu. This evidence concerns the gene CD8A and neoplasm.