The rs738409-G allele has previously been reported as associated with an increased risk for non-alcoholic fatty liver disease (NAFLD), alcohol-related cirrhosis and hepatic steatosis, as well as elevated alanine aminotransferase (ALT) levels, most likely through a gain-of-function (GOF) mechanism (Supplementary Methods). This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.