These three SNPs had similar allele frequencies in Europeans, had previously been shown to impact FXI, FXII, and/or KNG1 mRNA and/or protein levels, and are associated with activated partial thromboplastin time (aPTT), a biomarker of blood clotting, or venous thromboembolism (VTE) risk (Supplementary Methods and Supplementary Table 1). The gene discussed is F11; the disease is venous thromboembolism.