Interestingly, among the proteins that were previously shown to precipitate with H2A.Z, strongest binding and collective clustering in volcano plot (Fig. 5a) was observed for MTA1, HDAC2, RBBP4, and RBBP7, which are core components of the nucleosome remodeling and deacetylase (NuRD) complex that is involved in gene regulation23, and implicated in cancer and various other diseases6. The gene discussed is HDAC2; the disease is cancer.