PRPS2 and cervical squamous intraepithelial neoplasia: The knockdown of ADSS, PRPS2 and TKL gave significantly elevated AO staining in the CIN region, while candidate depletion in non-CIN cells gave little or no AO, similar to the negative control, in this case RNAi to a gene not expressed in Drosophila (mCherry) (Fig. 3C-G).