We did not observe any significant increase or decrease in PH3 staining in knockdowns of ADSS, PRPS2 and TKL in CIN or non-CIN cells (Fig. S3), suggesting that depletion of nucleotide synthesis enzymes does not arrest the cell cycle even in CIN cells showing DNA damage. Here, ADSS2 is linked to cervical squamous intraepithelial neoplasia.