Though the exact mechanism(s) by which PLXDC2 is involved in POAG development and/or progression is not yet clear, however, the genetic variant rs7081455 near PLXDC2 seems to contribute to glaucomatous optic neuropathy in an IOP-related mechanism, because this locus was associated with high-tension glaucoma rather than normal-tension glaucoma [6]. This evidence concerns the gene PLXDC2 and low tension glaucoma.