The AD risk association observed by Sims et al., with ABI3_rs616338-T was validated in our non-overlapping AD Replication cohort, which demonstrated an increased minor allele frequency (MAF) in the AD cases compared to the controls (MAFAD = 0.016, MAFcontrols = 0.011) despite the P values not reaching significance (Fisher’s odds ratio (OR) = 1.44, p = 0.116; LR OR = 1.49, p = 0.163). This evidence concerns the gene ABI3 and Alzheimer disease.