In this module, named AD+Ctrl.TCX14, ABI3 is one of the most well-connected genes with a module membership (MM) of 0.90, which places it as the fourth most well-connected AD candidate risk gene behind TYROBP, SPI1, and MS4A6A (Additional file 1: Table S4) and the 35th of 246 genes in this module (data not shown). This evidence concerns the gene SPI1 and Alzheimer disease.