Moreover, overexpression of E2F7 in miR-302a/d-transfected HepG2 cells led to significant G1 entry or promoted the entry of S phase in CD133+/EpCAM1+ hepatoma cells as compared with control (Fig. 5f), suggesting that E2F7 promotes cell cycle entry through the AKT1-p27Kip1/p21Cip1 pathway independent of miR-302a/d. The gene discussed is CDKN1B; the disease is hepatocellular carcinoma.