HSF1 is overexpressed in several cancer types, including colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), breast cancer (BC), hepatocellular carcinoma (HCC), osteosarcoma, non-small-cell lung cancer, clear cell renal cell carcinoma (ccRCC), etc. [12–18]. Here, HSF1 is linked to osteosarcoma.