Our previous studies showed that miR-196b-5p targets 3′-UTRs of SOCS1 and SOCS3 mRNA to promote STAT3 signaling pathway in colorectal cancer cells [22]. We then determined whether miR-196b-5p could promote STAT3 signaling pathway in macrophages through SOCS1 or SOCS3. This evidence concerns the gene SOCS3 and colorectal cancer.