In the multivariate analysis that included sex, chemotherapy history, tumor grade, tumor location, and synchronous or metachronous liver metastasis as the confounding variables, the CDX2 expression status was remaining variable and the HR for overall survival in the patients with CDX2-low versus those with CDX2-high was 3.38 (95% CI, 1.54–7.41; P = 0.002; Additional file 3: Table S2). Here, CDX2 is linked to neoplasm.