In the multivariate analysis that included sex, chemotherapy history, as well as tumor grade, tumor location, and synchronous or metachronous liver metastasis as the confounding variables, the hazard ratio (HR) for disease recurrence in the patients with CDX2-low versus those with CDX2-high was 1.64 (95% CI, 1.08–2.38; P = 0.02; Table 3). Here, CDX2 is linked to neoplasm.