IL4 and cancer: We aimed to observe the effects of ERS inhibition by 4PBA over IL4 in TUN-mediated inflammation where we observed a significant reduction of IL4 levels in the groups (4PBA and 4PBA + TUN), which was in line with previous findings where the blocking of IL4 signaling sensitized cancer stem cells (CSCs) to apoptotic stimuli and increased the in vivo efficacy of cytotoxic therapy [27].