Entrectinib, a tyrosine kinase inhibitor of both ALK and TrkB, also demonstrated potent activity anti-tumor activity when studied in mouse xenografts of neuroblastoma and is currently undergoing evaluation in a phase 1 clinical trial for children with recurrent or refractory solid tumors, with an arm specifically for neuroblastoma (NCT02650401) [78]. This evidence concerns the gene ALK and neoplasm.