Further preclinical studies have demonstrated that combined inhibition of ODC1 and AMD1 using DFMO and SEAM486 prior to tumor initiation profoundly reduced tumor penetrance in TH-MYCN neuroblastoma-prone mice, a transgenic mouse model that harbors mis-expression of the human MYCN gene in neural-crest derived cells [27]. The gene discussed is MYCN; the disease is neuroblastoma.