ERBB2 and ovarian carcinoma: The abovementioned click reaction protocol was applied for the PET imaging detection of HER2 in a mouse model with ovarian cancer in 2017 by 18F radiolabeling of a trivalent HER2-targeting aptamer and the alkyne-modified EGFR aptamer (ME07) via click chemistry by Cheng S. et al. in 2018 [62].