Indeed, limited evidence suggests the involvement of transient receptor potential canonical 5 (TRPC5), transient receptor potential melastatin 3 (TRPM3), transient receptor potential melastatin 7 (TRPM7), transient receptor potential melastatin 8 (TRPM8), transient receptor potential vanilloid 2 (TRPV2), and transient receptor potential vanilloid 4 (TRPV4) in the pathogenesis of arthritis in animal models. This evidence concerns the gene TRPC5 and arthritic joint disease.