Whether and how these alterations in TRPV1 levels affect the function of chondrocytes and the overall pathogenesis of arthritis is still to be determined, although results from a recent study of chondrocytes obtained from mouse and chicken embryos hints that TRPV1 activity may affect chondrocyte proliferation and extracellular matrix production [75]. The gene discussed is TRPV1; the disease is arthritic joint disease.