TRPA1 and gout: In a preclinical study using the MSU model of gout, Trevisan and colleagues demonstrated that the pain and swelling caused by H2O2 injection was unaffected by low doses of either HC-030031 (a TRPA1 antagonist) or SB-366791 (a TRPV1 antagonist) alone, but injection of low doses of these two antagonists simultaneously significantly reduced pain and swelling [60].