Likewise, injection of the TRPV1 antagonist capsezapine into the inflamed temporo-manibular joint of rats resulted in significantly reduced pain behaviors compared to controls [50], and injection of the TRPV1 antagonists SB366791, AMG9810, and ABT-116 in murine models of gouty arthritis also significantly reduced pain behaviors [51,52,53]. The gene discussed is TRPV1; the disease is gout.