Inhibition of Na/K-ATPase in renal tubules promotes natriuresis, whereas at the scenario of renal insufficiency excessive MBG production would cause an inhibition of NKA in arterial vascular smooth muscle cells, which leads to an elevation of cytosolic Ca2+ and vasoconstriction via activation of an ionic pathway [39,40]. The gene discussed is TAC1; the disease is Renal insufficiency.