SMPD1 and Sepsis: At 24 h following sepsis induction in desipramine pretreated SMPD1+/+ animals median CYP1A activities (EROD; Figure 7A) amounted to 154.4 (IQR 25%: 138.6 and IQR 75%: 252.1) pmol/(mg protein × min), median CYP1A, 2A, 2B and 2C activities (ECOD; Figure 7B) to 282.4 (IQR 25%: 268.4 and IQR 75%: 402.4) pmol/(mg protein × min) and median CYP2B activities (PROD; Figure 7C) to 80.4 (IQR 25%: 68.4 and IQR 75%: 91.2) pmol/(mg protein × min).