SMPD1 and Sepsis: In addition, hepatic Cyp2a5 expression was still found to be downregulated in SMPD1+/+ animals (−1.79 (IQR 25%: −2.65 and IQR 75%: −0.62) log2 fold change) at 28 days following polymicrobial sepsis, whereas heterozygous animals, again, demonstrated significantly improved values in comparison to septic wild-type mice (−0.27 (IQR 25%: −1.04 and IQR 75%: 1.04) log2 fold change) (Figure 3B).