As described above (Figure 3A–C), transcriptional expression of Cyp1a1 and Cyp2a5 was still significantly downregulated in SMPD1+/+ animals at 28 days following sepsis induction, whereas treating SMPD1+/+ littermates with desipramine resulted in improved Cyp1a1 (0.20 (IQR 25%: −0.64 and IQR 75%: 0.38) log2 fold change) and Cyp2a5 (−0.76 (IQR 25%: −0.88 and IQR 75%: −0.36) log2 fold change) expression rates (Figure 6A,B). This evidence concerns the gene SMPD1 and Sepsis.