CYP1A1 and Sepsis: Cyp1a1 expression in dSMPD1+/+ mice amounted to a median value of 0.73 (IQR 25%: 0.53 and IQR 75%: 1.40) log2 fold change, which was significantly higher as compared to the respective control animals (−0.11 (IQR 25%: −0.53 and IQR 75%: 0.25)) and to the SMPD1+/+ littermates at 24 h following sepsis induction (−1.08 (IQR 25%: −1.43 and IQR 75%: −0.85); Figure 6A).