As displayed in Figure 3B, induction of peritoneal sepsis resulted in the reduction of Cyp2a5 expression in SMPD1+/+ mice (control: 0.06 (IQR 25%: −0.4 and IQR 75%: 0.49) log2 fold change vs. 24 h: −4.32 (IQR 25%: −1.83 and IQR 75%: −0.93) log2 fold change), whereas SMPD1+/− animals (−2.66 (IQR 25%: −3.31 and IQR 75%: −0.98) log2 fold change; p ≤ 0.05) demonstrated a significantly less pronounced reduction of the values following sepsis induction as compared to SMPD1+/+ littermates. Here, SMPD1 is linked to Sepsis.