The expression rate of Cyp1a1 in SMPD1+/+ animals significantly decreased from a median control level set to 0.0 (IQR 25%: −0.08 and IQR 75%: 0.07) log2 fold change to −1.04 (IQR 25%: −1.83 and IQR 75%: −0.93) log2 fold change at 24 h following polymicrobial sepsis induction (Figure 3A). The gene discussed is SMPD1; the disease is Sepsis.