In addition, Cyp3a11 expression (Figure 3C) showed a significant decrease of the median value in SMPD1+/+ animals from −0.05 (IQR 25%: −0.61 and IQR 75%: 0.59) log2 fold change to −2.65 (IQR 25%: −3.41 and IQR 75%: −1.45) log2 fold change following sepsis induction. Here, SMPD1 is linked to Sepsis.