In contrast, partial SMPD1 deficiency in heterozygous littermates (SMPD1+/−) revealed a median value of 0.43 log2 fold change after sepsis induction (IQR 25%: −0.10 and IQR 75%: 1.85 log2 fold change), which was significantly increased in comparison to the control situation, but also significantly higher as compared to SMPD1+/+ mice following sepsis induction. Here, SMPD1 is linked to Sepsis.