Based on previous findings of our group showing a beneficial effect of the FIASMA desipramine on hepatic cytokine expression, oxidative stress, cholestasis and fibrotic changes in polymicrobial sepsis [25] and as a proof of concept for the present results, in the present study, we also tested the effect of this drug in SMPD1 wild-type mice on hepatic CYP mRNA expression and on monooxygenase activities following polymicrobial sepsis induction. This evidence concerns the gene SMPD1 and cholestasis.