SMPD1 and Sepsis: Induction of polymicrobial sepsis in SMPD1+/− littermates, in contrast, resulted in a diminished reduction of expression levels as compared to SMPD1+/+ mice (0.38 (IQR 25%: −0.47 and IQR 75%: 1.34) log2 fold change; p ≤ 0.05).