In contrast, SMPD1+/− mice (control: 230.7 (IQR 25%: 179.3 and IQR 75%: 275.7) pmol/(mg protein × min) vs. 24 h: 153.9 (IQR 25%: 138.1 and IQR 75%: 184.0) pmol/(mg protein × min)) demonstrated a significantly smaller decline in CYP1A activity 24 h following sepsis induction. Here, SMPD1 is linked to Sepsis.