Hepatic CYP1A activities, as assessed by EROD (Figure 4A), showed a significant reduction of the values in SMPD1+/+ animals 24 h after sepsis induction from a median value of 203.3 (IQR 25%: 189.5 and IQR 75%: 245.6) pmol/(mg protein × min) to 112.5 (IQR 25%: 97.8 and IQR 75%: 126.9) pmol/(mg protein × min). The gene discussed is SMPD1; the disease is Sepsis.