SMPD1 and Sepsis: At 24 h after sepsis induction, SMPD1+/+ animals displayed a significant decrease in enzyme activities (control: 291.9 (IQR 25%: 275.5 and IQR 75%: 348.8) pmol/(mg protein × min) vs. 24 h: 155.5 (IQR 25%: 99.2 and IQR 75%: 230.1) pmol/(mg protein × min); p ≤ 0.05).