SMPD1 and Sepsis: Similarly, the transcriptional expression of Cyp2a5 (−1.53 (IQR 25%: −1.94 and IQR 75%: −0.86) log2 fold change) as well as Cyp3a11 (0.90 (IQR 25%: −0.25 and IQR 75%: 0.96) log2 fold change) showed higher median values in dSMPD1+/+ mice as compared to the SMPD1+/+ littermates at 24 h following sepsis induction (Cyp2a5: −4.65 (IQR 25%: −5.67 and IQR 75%: −3.74); Cyp3a11 (−2.65 (IQR 25%: −3.22 and IQR 75%: −1.45)).