In SMPD1+/− littermates, in contrast, no significant influence of sepsis induction on enzyme activities could be observed (331.3 (IQR 25%: 227.5 and IQR 75%: 405.8) pmol/(mg protein × min)) as compared to the corresponding control group (422.6 (IQR 25%: 268.9 and IQR 75%: 655.5) pmol/(mg protein × min)). The gene discussed is SMPD1; the disease is Sepsis.