SMPD1 and Sepsis: Likewise, CYP2B activity as assessed by PROD (Figure 4C) was reduced from 82.3 (IQR 25%: 71.8 and IQR 75%: 90.9) pmol/(mg protein × min) to 63.7 (IQR 25%: 60.0 and IQR 75%: 67.5) pmol/(mg protein × min) (p ≤ 0.05) in SMPD1+/+ animals, whereas SMPD1+/− littermates (control: 85.3 (IQR 25%: 78.4 and IQR 75%: 114.2) pmol/(mg protein × min) vs. 24 h: 74.9 (IQR 25%: 71.2 and IQR 75%: 87.4) pmol/(mg protein × min)) showed no reduction of activities after sepsis induction and, consequently, significantly higher levels as compared to their respective septic wild-type mice (p ≤ 0.05).