Both animal groups showed a significant reduction of body temperature from a baseline median of 36.4 °C (SMPD1+/+) or 36.1 °C (SMPD1+/−), respectively, to a median of 34.7 °C (IQR 25%: 33.7 °C and IQR 75%: 35.2 °C) in wild-type or of 34.8 °C (IQR 25%: 33.6 °C and IQR 75%: 35.1 °C) in SMPD1+/− animals, respectively, at 6 h following sepsis induction. This evidence concerns the gene SMPD1 and Sepsis.