Triglyceride-lowering alleles in LPL were associated with lower risk of type 2 diabetes both in combined analyses (OR per SD of genetically lower triglycerides, 0.69; 95% CI, 0.62-0.76; P = 2.6 × 10−13) (eFigure 2 and eTable 4 in the Supplement) and individual-variant analyses (eFigure 3 and eTable 5 in the Supplement). The gene discussed is LPL; the disease is type 2 diabetes mellitus.