LPL and coronary artery disorder: People naturally randomized to lower LDL-C levels, lower triglyceride levels via LPL alleles, or both had a lower risk of coronary artery disease compared with the reference group, with the lowest odds in people naturally randomized to both genetic exposures (OR, 0.73; 95% CI, 0.70-0.76; P = 2.8 × 10−52) (Figure 1).