People naturally randomized to lower LDL-C had a higher risk of type 2 diabetes compared with the reference group (Figure 1), consistent with previous studies.43,50,52,53,54,55 However, people naturally randomized to both genetic exposures had a similar risk of type 2 diabetes compared with the reference group (Figure 1), as the association of LPL alleles with lower risk cancelled out the risk-increasing association of LDL-C–lowering alleles. Here, LPL is linked to type 2 diabetes mellitus.