In stratified analyses, triglyceride-lowering LPL alleles were strongly and consistently associated with protection from coronary disease and diabetes in subgroups of people above or below the median of the population distribution of the 58 LDL-C–lowering alleles (Figure 2A) and of the 22 of 58 LDL-C–lowering alleles that were not associated with triglyceride levels in GLGC (eTable 7 in the Supplement), HMGCR, NPC1L1, or PCSK9 alleles (Figure 2) (eFigure 5 in the Supplement). Here, HMGCR is linked to diabetes mellitus.