In a meta-analysis of published genetic studies5,6 on rare loss-of-function variants in ANGPTL3, we found an association with approximately 34% lower odds of coronary disease for carriers compared with noncarriers (OR, 0.66; 95% CI, 0.52-0.83; P < .001; I2 = 0%; P for heterogeneity = .99) (eFigure 8 in the Supplement). This evidence concerns the gene ANGPTL3 and coronary artery disorder.