To test whether RNAi-mediated knockdown can identify suppressors of epithelial tumor progression, we assayed Drosophila genes previously reported to have this function [14, 15, 24]; knockdown of Discs-large (Dlg) and Bazooka (Baz) resulted in large tumor formation with ectopic GFP+ foci (Fig 1A) and ventral nerve cord invasion (Fig 1B). Here, PARD3 is linked to neoplasm.