Further, we found that key nodes of regulation by our confirmed hits in this interaction map were known molecules that modulate survival, EMT and drug resistance in Ras mutated pancreatic cancers, such as YAP1 [41, 42], SIRT1 [43, 44], BAG3 [45, 46], ILK [47–49], CDK5 [50–52], HDACs or GSK3β [53, 54]. This evidence concerns the gene SIRT1 and familial pancreatic carcinoma.