Similarly, in a subgroup of The European Randomized study of Screening for Prostate Cancer (ERSPC), subjects with baseline PSA > 1.0 ng / mL and > 2.0 ng / mL had an increased hazard ratio for prostate cancer specific mortality (4.0 - fold and 7.6 - fold respectively) compared with those who had < 1.0 ng / mL levels (2). Here, KLK3 is linked to Familial prostate cancer.