AR and preeclampsia: A recent study also indicated that overexpression of CYP11A1 mRNA (commonly referred as cholesterol side-chain cleavage enzyme that catalyzes the first steps of steroidogenesis) in human trophoblast cells induces increased testosterone production and preeclampsia-like placental dysfunction that could be reversed with flutamide, an androgen receptor antagonist (Pan et al. 2017).