In our study, we confirmed the specificity of nuclear p65‐RelA IHC in a series of pediatric supratentorial ependymomas, and further report the absence of p65‐RelA nuclear staining in a large series of control pediatric infratentorial ependymomas, mixed ependymomas/subependymoma, YAP‐fused ependymomas as well as in histological mimics including “HGNET, MN1” tumors. Here, YAP1 is linked to supratentorial ependymoma.