A previous study has demonstrated that MYC represses p21Cip1 transcription through recruitment of DNMT3A.42 MYC directly binds to and represses the miR‐200b promoter in endometrial carcinoma cells.43 Furthermore, DNMT3A knockdown increases miR‐200b expression.44 Then, we wondered whether MYC is responsible for the epigenetic repression of miR‐200b via interacting with DNMT3A. The gene discussed is CDKN1A; the disease is endometrial carcinoma.