DNMT3B and hepatocellular carcinoma: In hepatocellular carcinoma, MYC repressed miR‐101 expression by recruiting EZH2 to the promoter regions of miR‐101.40 During Helicobacter pylori‐related carcinogenesis, MYC, DNMT3B and EZH2 interacted with each other and led to let‐7c silencing by inducing histone methylation and DNA hypermethylation.41 However, the role of MYC in epigenetically regulating miR‐200 expression is still unclear.