The liver is central to glucose homeostasis by the conversion of glucose into glycogen in the postprandial state and by the conversion of glycogenolysis into glucose in the fasting state.26 The glycogen levels in the muscles and liver are an immediate reflection of insulin sensitivity because insulin encourages intracellular glycogen deposition via a coordinated elevation in glucose movement and glycogen synthesis.12 Insulin resistance is distinguished by damage in muscle glucose uptake and the overproduction of glucose in the liver. The gene discussed is INS; the disease is Insulin resistance.