Saponins from the seed of Entada phaseoloides significantly lowered FBG, serum insulin levels and reduced hyperglycemia in T2DM rats.11 In addition, the saponins from the root of Panax notoginseng lowered FBG levels and revealed anti‐hyperglycemic effects on KK‐Ay mice.20, 25 These results demonstrated that saponins could improve glucose homeostasis and insulin resistance. This evidence concerns the gene INS and type 2 diabetes mellitus.