Sequencing of the 61 CRC patients revealed 11 rare coding variants in CRC genes: six variants in MLH1, one variant in MSH6, one variant in PMS2, and three variants in APC. We examined literature and clinical trial submission data collected by ClinVar19 with respect to pathogenicity, six out of the 11 variants have been previously reported by ClinVar. The gene discussed is APC; the disease is colorectal carcinoma.