2012). PDGF is also involved in structural alterations of DKD. Di Paolo et al. (1996) demonstrated that HG induced a persistent increase in PDGFB expression, thus stimulating fibroblast proliferation, collagen and ECM production. Ramipril, eplerenon, irbesartan and spironolactone decreased PDGFB in experimental hepatic (Li et al. 2005), myocardial (Nishioka et al. 2007) and atrial fibrosis (Yang et al. 2013) and in cyclosporine nephrotoxicity (Macunluoglu et al. 2008). The gene discussed is PDGFB; the disease is diabetic kidney disease.