2015). They contribute to the fibrotic process by enabling fibroblasts to differentiate and migrate, which eventually induces the expression of ECM components including collagen type III and MMP9 (Powell et al. 1999). In the present study, we demonstrated that monotherapy with various RAASi successfully regulates the hyperglycaemia‐induced fibrotic response and supresses the level of profibrotic factors both in vivo and in vitro. Here, MMP9 is linked to Hyperglycemia.