ACE and renal fibrosis: 2013). The antifibrotic potential of angiotensin II receptor 2 agonism (Morrissey & Klahr, 1999), and AT1 antagonism (Gross et al. 2004), as well as ACE inhibition (Rubel et al. 2014), has been already explored in murine models of unilateral ureteral obstruction and progressive renal fibrosis. Furthermore, RAASi have already been shown to reduce renal fibrosis in DKD (Liao et al. 2003; Han et al. 2006; Feldman et al. 2008), but the complexity of the exact mechanisms is still not fully clarified.