More specifically, motivated by the hypothesis that visual cortex neurochemistry and structure might be altered due to the fact that the OPA1 gene is expressed in the brain, we performed cortical thickness and volumetric analysis, and also in vivo neurochemical analysis using proton MR spectroscopy (1H-MRS) in the occipital cortex of a group of OPA1-ADOA patients from a previously studied cohort in a vision research study [22] to (indirectly) assess neurotransmission. The gene discussed is OPA1; the disease is autosomal dominant optic atrophy.