In AD mouse models, PF11 treatment at doses of 1.6 and 8 mg/kg for 15 days significantly mitigated Aβ1-42-induced learning and memory impairment and PF11 treatment at a dose of 8 mg/kg for 4weeks 8 mg/kg dose for 4 weeks improved memory in APP/PS1 mice in behavioral studies. This evidence concerns the gene PSEN1 and Alzheimer disease.