Proteomic analysis revealed that downregulation of complexin-2, synapsin-2, and synaptosomal-associated protein 25 in the hippocampus of 3xTg-AD mice was significantly greater than that in compared with the WT mice, and Rg1 treatment modulated the expression of complexin-2 and synaptosomal-associated protein 25 in the hippocampus of 3xTg-AD mice [97]. Here, CPLX2 is linked to Alzheimer disease.