ACHE and memory impairment: Ginsenoside Rg3 had effects in both scopolamine- and LPS-induced memory impairment in models [99–101] In the scopolamine-induced memory impairment mouse model, Rg3 [50 and 100 mg/kg, per oral (p.o.)] suppressed the scopolamine-mediated increase in AChE activity and stimulation of the NF-κB pathway (i.e., phosphorylation of p65) in the hippocampus [100].