We found a significantly reduced expression of Notch-1 mRNA in mucinous CRC when compared with CRC tissues in the TCGA Colorectal (n, CRC/Mucinous CRC=186/28); Bittner Colon (n, 324/45); and Kaiser Colon (n, 75/17) datasets (Figure 5A-5C). This evidence concerns the gene NOTCH1 and colorectal carcinoma.