Our data indicate that the enhanced lung metastasis is mediated by an increase in tumor cell adhesion to SSeCKS-null lung endothelial cells and by an increased secretion of soluble factors by SSeCKS-null lung fibroblasts that upregulate E- and P-Selectins, known tumor cell adhesion factors [26], on lung endothelial cells. The gene discussed is SELP; the disease is neoplasm.