SSeCKS/AKAP12 expression is downregulated in many human cancers compared to normal, untransformed tissues, but its greatest relative losses are found in metastatic lesions, where its transcriptional downregulation and/or gene deletion correlate with metastatic progression in colon, gastric, esophageal and prostate cancer in a tumor cell autonomous manner [19]. The gene discussed is AKAP12; the disease is Familial prostate cancer.