Consistent with the notion that a Src-Stat3 axis in KO-LF drives melanoma adhesion on endothelial, we showed that re-expression of full-length SSeCKS or SSeCKS variants deleted of their PKA-, PKC- or PLK1-scaffolding domains, but not SSeCKS deleted of its Src-scaffolding domain, could suppress IFNα-induced STAT3 activation in KO-LF. This evidence concerns the gene PLK1 and melanoma.