Here, we analyze roles for the SSeCKS/AKAP12 metastasis suppressor in resident endothelial cells and fibroblasts that control metastatic colonization of melanoma cells in the lung, using syngeneic BrafWT and BrafC600E melanomas in immunocompetent WT or SSeCKS-null (KO) hosts. The gene discussed is AKAP12; the disease is melanoma.