RN765C is able to utilize three mechanisms to inhibit tumor growth: 1) active cell killing mediated by its potent payload PF-06380101, 2) blocking of EGFR signaling pathway due to ligand blocking property of its parental antibody, and 3) antibody dependent cell cytotoxicity provided by human IgG1 backbone (Table 2, Figure 3 and Supplementary Figure 2). This evidence concerns the gene EGFR and neoplasm.