For human keratinocytes it requires ∼ 70 nM of RN765C to achieve 50% of cell killing in vitro (which is partly driven by non-receptor mediated pinocytosis) whereas the same level of killing can be achieved with sub-nanomolar to low nanomolar of RN765C in many tumor cell lines expressing > 50,000 EGFR/cell (Figure 3A, 3B and 3C, and Table 2). This evidence concerns the gene EGFR and neoplasm.