Adachi et al. [48] showed that fasting and postolive oil-loaded TG levels and atherosclerotic lesion size were largely decreased in ApoE(-/-)/ANGPTL4(-/-) mice compared with ApoE(-/-)/ANGPTL4(+/+) mice, and that genetic knockout of ANGPTL4 protected ApoE(-/-) mice against development and progression of atherosclerosis and strongly suppressed the ability of the macrophages to become foam cells in vitro. This evidence concerns the gene APOE and atherosclerosis.