As compared with the controls, more CAD/IS patients had T2DM, hypertension and hyperlipidemia; and the CAD/IS patients also had higher BMI, systolic blood pressure, pulse pressure, serum TG levels, the frequency of using lipid-lowering drugs, and lower serum TC, HDL-C, ApoA1 levels, the ApoA1/ApoB ratio and the percentages of subjects who consumed alcohol (P < 0.05). The gene discussed is APOB; the disease is hyperlipidemia.