EP300 and schizophrenia: Interestingly, the DNM (NM_001429, exon14, c.C2656G, p.P886A) found in EP300 is not predicted as damaging by either SIFT nor PolyPhen2, and a common missense variant in EP300 is also strongly associated with schizophrenia (rs20551, P = 1.38 × 10−8; NM_001429, exon15, c.A2989G, p.I997V), which suggest that slight changes in the protein conformation of EP300 may confer risk to schizophrenia.