Moreover, in this network, we found multiple genes are connected with the core members of NMDAR interactome, such as ATP2B2, DLGAP, MAP1A, NOS1, PTK2B, PTPRG and PRKCA. Among them, ATP2B2 (rs9879311, P = 2.77 × 10−6) and NOS1 (rs2293052, P = 1.24 × 10−6) exhibited strong associations with schizophrenia risk in the PGC2 GWAS. This evidence concerns the gene PTK2B and schizophrenia.