Besides, previous studies found that the down-regulation of miR-200c and miR-141 is associated with elevated ZEB1 (Wiklund et al., 2011; Shan et al., 2013; Mahdavinezhad et al., 2015), and the down-regulation of miR-200c is also coupled with the down-regulation of BMI-1 and E2F3 (Liu et al., 2014), which play an important role in the invasion, migration, and EMT of bladder cancer. This evidence concerns the gene E2F3 and urinary bladder cancer.