Brunet et al. used ZFNs and TALENs in human cells, including embryonic stem cell-derived mesenchymal precursors to generate t(11;22)(q24;q12) EWSR1-FLI1 fusion and t(2;5)(p23;q35) NMP1-ALK fusion genomic translocations associated with Ewing sarcoma and anaplastic large cell lymphoma, respectively, or to revert the t(2;5)(p23;q35) NMP1-ALK translocation (95). Here, ALK is linked to Ewing sarcoma.