A study of patients with cutaneous systemic sclerosis (SSc), an autoimmune disease associated with B cell hyperactivation and the production of autoantibodies, showed a significant association between SSc disease susceptibility and synonymous SNP c.2304C > A (P768P, rs34826052) located within exon 13 of the CD22 gene (86). This evidence concerns the gene CD22 and autoimmune disease.